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1

2700 Final results of ARIEL2 (Part 1): A phase 2 trial to prospectively identify ovarian cancer (OC) responders to rucaparib using tumor genetic analysis

Kristeleit, R., Swisher, E., Oza, A., Coleman, R.L., Scott, C., Konecny, G., Tinker, A., O'Malley, D.M., Brenton, J., Bell-McGuinn, K., Oaknin, A., Leary, A., Lin, K.K., Raponi, M., Giordano, H., Malo

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 60 KB

english, 2015

2

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

Swisher, Elizabeth M, Lin, Kevin K, Oza, Amit M, Scott, Clare L, Giordano, Heidi, Sun, James, Konecny, Gottfried E, Coleman, Robert L, Tinker, Anna V, O'Malley, David M, Kristeleit, Rebecca S, Ma, Lin

Journal:

The Lancet Oncology

Year:

2016

Language:

english

File:

PDF, 457 KB

english, 2016

3

993OOCTOPUS: A randomised, multi-centre phase II umbrella trial of weekly paclitaxel+/- novel agents in platinum-resistant ovarian cancer: Vistusertib

Banerjee, S, Lewsley, L-A, Clamp, A R, krell, J, Herbertson, R, Glasspool, R M, Orbegoso, C, Green, C, Kristeleit, R S, Gourley, C, Cambell, C, Banerji, U, Shepherd, C, Brugger, W, Chudleigh, L, Hanif

Journal:

Annals of Oncology

Year:

2019

Language:

english

File:

PDF, 109 KB

english, 2019

4

Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers

Bartlett, J B, Michael, A, Clarke, I A, Dredge, K, Nicholson, S, Kristeleit, H, Polychronis, A, Pandha, H, Muller, G W, Stirling, D I

Journal:

British Journal of Cancer

Year:

2004

Language:

english

File:

PDF, 193 KB

english, 2004

5

Histone Deacetylase Inhibitors: Emerging Anticancer Therapeutic Agents?

Rebecca Kristeleit, Peter Fong, G. Wynne Aherne, Johann de Bono

Journal:

Clinical Lung Cancer

Year:

2005

Language:

english

File:

PDF, 1.08 MB

english, 2005

6

Basic science of lung cancer

Hartmut Kristeleit, Deborah Enting, Rohit Lai

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

7

Systemic treatment of non-small-cell lung cancer

Rohit Lal, Deborah Enting, Hartmut Kristeleit

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 48 KB

english, 2011

8

1234 POSTER A First in Man Phase 1 Study of JNJ-26481585, a Novel Oral Histone Deacetylase Inhibitor (HDACi) in Advanced Cancer Patients -Evidence of Target Modulation, Antitumour Activity and Additional Safety Data in an Expanded Patient Cohort

A. Omlin, B. Venugopal, R. Kristeleit, K. Shah, N. Fourneau, P. Hellemans, J. de Bono, R. Plummer, U. Banerji, J. Evans

Journal:

European Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 61 KB

english, 2011

9

Dose intensity in advanced non-small cell lung cancer

Brunetto, A., Carden, C.P., Ashley, S., Baird, R., Myerson, J., Kristeleit, R., Montes, A., Popat, S., O'Brien, M.

Journal:

Year:

2008

Language:

english

File:

PDF, 43 KB

english, 2008

10

58 Pharmacodynamic responses to a novel histone deacetylase inhibitor, PXD101, in mice and humans

J.A. Plumb, N. Steele, T.R.J. Evans, P.W. Finn, P.B. Jensen, R. Kristeleit, J. DeBono, R. Brown

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 140 KB

english, 2004

11

1204 A Phase I study evaluating the pharmacokinetics (PK) and pharmacodynamics (PD) of the oral pan-phosphoinositide-3 kinase (PI3K) inhibitor GDC-0941

R. Kristeleit, D. Sarker, M. Forster, M. Lolkema, D. Olmos, K. Mazina, M.V. Dolezal, J.A. Ware, Y. Yan, J.S. de Bono

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 50 KB

english, 2009

12

1255 Clinical and preclinical development of 4SC-201, a new oral histone deacetylase (HDAC) inhibitor

J. de Bono, A.T. Brunetto, R. Kristeleit, A. Mais, B. Hauns, B. Hentsch

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 49 KB

english, 2009

13

1257 Retrospective analysis of unplanned hospital admissions: an early surrogate indicator of patient (pt) attrition in phase-I trials

D. Olmos, A. Brunetto, J. Ang, D. Tan, S. Sandhu, R. Kristeleit, M. Lolkelma, M. Forster, R. Molife, S. Kaye

Journal:

European Journal of Cancer Supplements

Year:

2009

Language:

english

File:

PDF, 70 KB

english, 2009

14

Histone modification enzymes: novel targets for cancer drugs

Kristeleit, Rebecca, Stimson, Lindsay, Workman, Paul, Aherne, Wynne

Journal:

Expert Opinion on Emerging Drugs

Year:

2004

Language:

english

File:

PDF, 544 KB

english, 2004

15

Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women’s cancers

Jones, Allison, Lechner, Matthias, Fourkala, Evangelia-Ourania, Kristeleit, Rebecca, Widschwendter, Martin

Journal:

Year:

2010

Language:

english

File:

PDF, 8.56 MB

english, 2010

16

Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer

Forster, Martin D., Dedes, Konstantin J., Sandhu, Shahneen, Frentzas, Sophia, Kristeleit, Rebecca, Ashworth, Alan, Poole, Christopher J., Weigelt, Britta, Kaye, Stan B., Molife, L. Rhoda

Journal:

Nature Reviews Clinical Oncology (formerly Nature Clinical Practice Oncology)

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

17

Phase II, open-label trial to assess QTcF effects, pharmacokinetics and antitumor activity of afatinib in patients with relapsed or refractory solid tumors

Molife, L. Rhoda, Rudman, Sarah M., Alam, Salma, Tan, Daniel S.-W., Kristeleit, Hartmut, Middleton, Gary, Propper, David, Bent, Liz, Stopfer, Peter, Uttenreuther-Fischer, Martina, Wallenstein, Gudrun,

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2013

Language:

english

File:

PDF, 697 KB

english, 2013

18

599 Effect of Food On Relative Bioavailability of E7820 in Cancer Patients

Slater, S., Witteveen, P.O., Plummer, R., Kristeleit, R., Evans, T.R.J., Reyderman, L., de las Heras, B., Verbel, D., Ink, B., Schellens, J.H.M.

Journal:

European Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 57 KB

english, 2012

19

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of a Novel Histone Deacetylase Inhibitor, LAQ824, in Human Colon Carcinoma Cells and Xenografts

Chung, Yuen-Li, Troy, Helen, Kristeleit, Rebecca, Aherne, Wynne, Jackson, L. Elizabeth, Atadja, Peter, Griffiths, John R., Judson, Ian R., Workman, Paul, Leach, Martin O., Beloueche-Babari, Mounia

Journal:

Year:

2008

Language:

english

File:

PDF, 624 KB

english, 2008

20

A randomised, placebo-controlled trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer

McNeish, I. A., Ledermann, J. A., Webber, L., James, L., Kaye, S. B., Hall, M., Hall, G., Clamp, A., Earl, H., Banerjee, S., Kristeleit, R., Raja, F., Feeney, A., Lawrence, C., Dawson-Athey, L., Persi

Journal:

Annals of Oncology

Year:

2014

Language:

english

File:

PDF, 286 KB

english, 2014

21

Nitrite and Nitrate Levels in Patients with Cirrhosis of the Liver: Influence of Kidney Function and Fasting State

J. Heller, H. Kristeleit, K.-A. Bre,

Journal:

Scandinavian Journal of Gastroenterology

Year:

1999

Language:

english

File:

PDF, 103 KB

english, 1999

22

Developing an objective marker to optimize patient selection and predict survival benefit in early-phase cancer trials

Stavraka, Chara, Pinato, David J., Turnbull, Samantha J., Flynn, Michael J., Forster, Martin D., O'Cathail, Sean M., Babar, Sayed, Seckl, Michael J., Kristeleit, Rebecca S., Blagden, Sarah P.

Journal:

Year:

2014

Language:

english

File:

PDF, 281 KB

english, 2014

23

First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors

Sarker, D., Ang, J. E., Baird, R., Kristeleit, R., Shah, K., Moreno, V., Clarke, P. A., Raynaud, F. I., Levy, G., Ware, J. A., Mazina, K., Lin, R., Wu, J., Fredrickson, J., Spoerke, J. M., Lackner, M.

Journal:

Clinical Cancer Research

Year:

2015

Language:

english

File:

PDF, 696 KB

english, 2015

24

Prediction of early death among patients enrolled in phase I trials: development and validation of a new model based on platelet count and albumin

Ploquin, A, Olmos, D, Lacombe, D, A'Hern, R, Duhamel, A, Twelves, C, Marsoni, S, Morales-Barrera, R, Soria, J-C, Verweij, J, Voest, E E, Schöffski, P, Schellens, J H, Kramar, A, Kristeleit, R S, Arken

Journal:

British Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

25

Early oncology clinical trial design in the era of molecular-targeted agents

Brunetto, Andre T, Kristeleit, Rebecca S, de Bono, Johann S

Journal:

Future Oncology

Year:

2010

Language:

english

File:

PDF, 458 KB

english, 2010

26

Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors

de Bono, J. S., Kristeleit, R., Tolcher, A., Fong, P., Pacey, S., Karavasilis, V., Mita, M., Shaw, H., Workman, P., Kaye, S., Rowinsky, E. K., Aherne, W., Atadja, P., Scott, J. W., Patnaik, A.

Journal:

Clinical Cancer Research

Year:

2008

Language:

english

File:

PDF, 393 KB

english, 2008

27

Optimal treatment for relapsing ovarian cancer

Ledermann, J. A., Kristeleit, R. S.

Journal:

Annals of Oncology

Year:

2010

Language:

english

File:

PDF, 157 KB

english, 2010

28

A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors

Venugopal, B., Baird, R., Kristeleit, R. S., Plummer, R., Cowan, R., Stewart, A., Fourneau, N., Hellemans, P., Elsayed, Y., Mcclue, S., Smit, J. W., Forslund, A., Phelps, C., Camm, J., Evans, T. R. J.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 652 KB

english, 2013

29

A Phase I Pharmacokinetic and Pharmacodynamic Study of CHR-3996, an Oral Class I Selective Histone Deacetylase Inhibitor in Refractory Solid Tumors

Banerji, U., van Doorn, L., Papadatos-Pastos, D., Kristeleit, R., Debnam, P., Tall, M., Stewart, A., Raynaud, F., Garrett, M. D., Toal, M., Hooftman, L., De Bono, J. S., Verweij, J., Eskens, F. A.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 761 KB

english, 2012

30

Second-line dovitinib (TKI258) in patients with FGFR2-mutated or FGFR2-non-mutated advanced or metastatic endometrial cancer: a non-randomised, open-label, two-group, two-stage, phase 2 study

Konecny, Gottfried E, Finkler, Neil, Garcia, Agustin A, Lorusso, Domenica, Lee, Paula S, Rocconi, Rodney P, Fong, Peter C, Squires, Matt, Mishra, Kaushal, Upalawanna, Allison, Wang, Yongyu, Kristeleit

Journal:

The Lancet Oncology

Year:

2015

Language:

english

File:

PDF, 554 KB

english, 2015

31

First-in-human, Pharmacokinetic and Pharmacodynamic Phase I Study of Resminostat, an Oral Histone Deacetylase Inhibitor, in Patients with Advanced Solid Tumors

Brunetto, A. T., Ang, J. E., Lal, R., Olmos, D., Molife, L. R., Kristeleit, R., Parker, A., Casamayor, I., Olaleye, M., Mais, A., Hauns, B., Strobel, V., Hentsch, B., de Bono, J. S.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 916 KB

english, 2013

32

A phase I study of daily afatinib, an irreversible ErbB family blocker, in combination with weekly paclitaxel in patients with advanced solid tumours

Suder, A., Ang, J.E., Kyle, F., Harris, D., Rudman, S., Kristeleit, R., Solca, F., Uttenreuther-Fischer, M., Pemberton, K., Pelling, K., Schnell, D., de Bono, J., Spicer, J.

Journal:

European Journal of Cancer

Year:

2015

Language:

english

File:

PDF, 763 KB

english, 2015

33

P06.06 * EFFECTS OF TASISULAM SODIUM ON THE PHARMACOKINETICS OF TOLBUTAMIDE IN PATIENTS WITH ADVANCED SOLID TUMOURS

Twelves, C. J., Wilkins, D. K., Anthoney, A., Chappell, J., Ng, W. T., Turner, P. T., Kristeleit, R.

Journal:

Annals of Oncology

Year:

2013

File:

PDF, 34 KB

2013

34

O3.4 * A first-in-human study of intravenous BAL101553, a novel microtubule inhibitor, in patients with advanced solid tumors

Rhoda Molife, L., King, J., Smith, A., D'arcangelo, M., Brown, N., Diamantis, N., Lane, H., Schmitt Hoffmann, A. H., Engelhardt, M., Plummer, R., Kristeleit, R.

Journal:

Annals of Oncology

Year:

2015

Language:

english

File:

PDF, 30 KB

english, 2015

35

P06.06 * EFFECTS OF TASISULAM SODIUM ON THE PHARMACOKINETICS OF TOLBUTAMIDE IN PATIENTS WITH ADVANCED SOLID TUMOURS

Twelves, C. J., Wilkins, D. K., Anthoney, A., Chappell, J., Ng, W. T., Turner, P. T., Kristeleit, R.

Journal:

Annals of Oncology

Year:

2013

Language:

english

File:

PDF, 34 KB

english, 2013

36

Homologous recombination deficiency and ovarian cancer

Ledermann, Jonathan A., Drew, Yvette, Kristeleit, Rebecca S.

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 1.09 MB

english, 2016

37

Long-term Follow-up Data from Pivotal Studies of Adjuvant Trastuzumab in Early Breast Cancer

Kristeleit, Hartmut, Parton, Marina, Beresford, Mark, Macpherson, Iain R., Sharma, Rajan, Lazarus, Loren, Kelleher, Muireann

Journal:

Targeted Oncology

Year:

2016

Language:

english

File:

PDF, 939 KB

english, 2016

38

PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions

Konecny, G E, Kristeleit, R S

Journal:

British Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 619 KB

english, 2016

39

Outcome of patients with advanced ovarian cancer who do not undergo debulking surgery: A single institution retrospective review

Marchetti, Claudia, Kristeleit, Rebecca, McCormack, Mary, Mould, Tim, Olaitan, Adeola, Widschwendter, Martin, MacDonald, Nicola, Ledermann, Jonathan A

Journal:

Gynecologic Oncology

Year:

2016

Language:

english

File:

PDF, 334 KB

english, 2016

40

A phase I study of afatinib combined with paclitaxel and bevacizumab in patients with advanced solid tumors

Spicer, James, Irshad, Sheeba, Ang, Joo Ern, Enting, Deborah, Kristeleit, Rebecca, Uttenreuther-Fischer, Martina, Pemberton, Karine, Pelling, Katy, Schnell, David, de Bono, Johann

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 644 KB

english, 2017

41

Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies

Dirix, Luc, Swaisland, Helen, Verheul, Henk M.W., Rottey, Sylvie, Leunen, Karin, Jerusalem, Guy, Rolfo, Christian, Nielsen, Dorte, Molife, L. Rhoda, Kristeleit, Rebecca, Vos-Geelen, Judith de, Mau-Sør

Journal:

Clinical Therapeutics

Year:

2016

Language:

english

File:

PDF, 351 KB

english, 2016

42

Clinical activity of the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib in patients (pts) with high-grade ovarian carcinoma (HGOC) and a BRCA mutation (BRCAmut): Analysis of pooled data from Study 10 (parts 1, 2a, and 3) and ARIEL2 (parts 1 and 2)

Kristeleit, R.S., Shapira-Frommer, R., Oaknin, A., Balmaña, J., Ray-Coquard, I.L., Domchek, S., Tinker, A.V., Castro, C.M., Welch, S., Poveda, A.M., Bell-Mcguinn, K., Konecny, G., Giordano, H., Malone

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 41 KB

english, 2016

43

Clinical factors of response in patients with advanced ovarian cancer participating in early phase clinical trials

George, Angela, Kristeleit, Rebecca, Rafii, Saeed, Michie, Caroline O., Bowen, Rebecca, Michalarea, Vasiliki, van Hagen, Tom, Wong, Mabel, Rallis, Grigorios, Molife, L. Rhoda, Lopez, Juanita, Banerji,

Journal:

European Journal of Cancer

Year:

2017

Language:

english

File:

PDF, 294 KB

english, 2017

44

A Phase I-II Study of the Oral Poly(ADP-ribose) Polymerase Inhibitor Rucaparib in Patients with Germline BRCA1/2-mutated Ovarian Carcinoma or Other Solid Tumors

Kristeleit, Rebecca, Shapiro, Geoffrey I., Burris, Howard A., Oza, Amit M, LoRusso, Patricia M., Patel, Manish, Domchek, Susan M., Balmaña, Judith, Drew, Yvette, Chen, Lee-may, Safra, Tamar, Montes, A

Journal:

Clinical Cancer Research

Year:

2017

Language:

english

File:

PDF, 1.07 MB

english, 2017

45

Outcome of Patients With Advanced Ovarian Cancer Who Do Not Undergo Debulking Surgery

Marchetti, Claudia, Kristeleit, Rebecca, McCormack, Mary, Mould, Tim, Olaitan, Adeola, Widschwendter, Martin, MacDonald, Nicola, Ledermann, Jonathan A.

Journal:

Obstetric and Gynecologic Survey

Year:

2017

Language:

english

File:

PDF, 86 KB

english, 2017

46

Immunohistochemistry (IHC) evaluation of a novel 4-protein prognostic and predictive biomarker panel in endometrial cancer (EC)

Kularatne, B., Arora, R., Elshstein, G., Guppy, N., Kirkwood, A., Meyer, T., Kristeleit, R.S.

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 80 KB

english, 2016

47

Uterine carcinosarcoma: a retrospective clinical cohort analysis

Perna, C., Eminowicz, G., Asghar, U., Imseeh, G., Kirkwood, A., Mitra, A., Arora, R., Kristeleit, R.S., McCormack, M.

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 37 KB

english, 2016

48

A first-in-human (FIH) phase I/II, dose escalation, pharmacokinetic (PK) study to assess the safety and tolerability of VAL-201 in patients with advanced prostate cancer (APC) and other advanced solid tumours

Kristeleit, R.S., Miller, R.E., Sellers, L.E., Brown, N.F., Gougis, P., Boyd, A., Morris, G., Payne, H., Hughes, S., Forster, M., Linch, M.

Journal:

Annals of Oncology

Year:

2016

Language:

english

File:

PDF, 104 KB

english, 2016

49

A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)–only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer

Kristeleit, Rebecca, Davidenko, Irina, Shirinkin, Vadim, El-Khouly, Fatima, Bondarenko, Igor, Goodheart, Michael J., Gorbunova, Vera, Penning, Carol A., Shi, Jack G., Liu, Xiangdong, Newton, Robert C.

Journal:

Gynecologic Oncology

Year:

2017

Language:

english

File:

PDF, 700 KB

english, 2017

50

Switching from standard to dose-dense chemotherapy in front-line treatment of advanced ovarian cancer: a retrospective study of feasibility and efficacy

Milani, Andrea, Kristeleit, Rebecca, McCormack, Mary, Raja, Fharat, Luvero, Daniela, Widschwendter, Martin, MacDonald, Nicola, Mould, Tim, Olatain, Adeola, Hackshaw, Allan, Ledermann, Jonathan A

Journal:

Year:

2017

Language:

english

File:

PDF, 993 KB

english, 2017

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